Anti-aging
TENSYLINE^®

TENSYLINE^® erases wrinkles caused by aging process and repeated expression movements. It presents a real Botox Like effect by blocking muscles contraction. It also promotes Collagen and Elastin synthesis and fights against its destruction by environmental factors, especially UVB light, by the inhibition of the Metalloproteinases production, main enzymes in the skin structure degradation cascade.

Additionally, TENSYLINE^® improves hydration and nutrition of the skin cells which attenuates dryness and rigidity of the epidermis, characteristic of wrinkle formation. TENSYLINE^® components provide special protection to elastic fibres trough which the fibroblasts are anchored in the Extracellular Matrix (ECM).

The Innovative Lyophilization process, on the one hand, allows to mix actives very unstable in solution and no compatible each other and on the other hand enable the concentration to be well balanced and optimized rendering a high efficient composition.

INTENSIVE WRINKLES TREATMENT

Main indications:
TENSYLINE^®, efficiently, fights against any face skin wrinkle, especially those localized in:

• The top of the nose bridge.
• The frown lines.
• The forehead lines.
• The Jaw line.
• The Worry lines or any other expression lines.
• The crow´s feet.
• The Neck and the cleavage lines.

These are advisable therapeutic uses. The ingredients of products may allow the Physician to apply them under professional criteria. The Physician may find the product optimal to treat other aesthetic issues.

Treatment areas:
Face, neck and cleavage.
TENSYLINE^® administration should be done under the supervision of or by Physician or Registered Nurse, applying the best technique available in each case.

71 ingredients to, efficiently, fight against the decline of dermal Collagen and Elastic Fibres, key factor in wrinkles formation:

Main Actives, 13 BIOMIMETIC PEPTIDES: Palmitoyl Tripeptide-28, Palmitoyl Tripeptide-38, Oligopeptide-24, Hexapeptide-8, Tetrapeptide, Acetyl Decapeptide-3, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Copper tripeptide-1, Decapeptide-4, Hexapeptide-10, Dipeptide Diaminobutyroyl Benzylamide Diacetate and Acetyl Octapeptide-3.

2 Bio-Factors: Plasma Body Like55 (PBL55), and Hyaluronic Acid (medical injection grade IP05K^®)

2 Booster agents: DMAE and Idebenone.

The balanced formula of TENSYLINE^®, combining 13 Mimetic Biotech Peptides, well documented Botox Like actives, presents the following actions:

Blockade of the neuron-muscle connection by inhibiting SNARE Complex which is essential for the connection between neurons and muscles, so the muscles can not contract and the expression lines disappear. These Peptides have similar structure than SNAP-25.
Acting over the action of UV radiation by inhibiting the degradation of I-KB that activates NF-KB that promote transcription of genes responsible of the formation of Metalloproteinases, specially MMP-1 that cause degradation of Collagen fibres.
Increment of the Collagen and Elastin gene expression: Collagen and Elastin are the main proteins of the Extra-Cellular Matrix. They are the structure that supports the dermis.
Promotion of the cohesion between Extracellular Matrix and Fibroblasts by up regulation of Fibuline-5, Fibrilin-1 and Integrins. The Non adhesion of Fibroblasts with the Collagen and Elastin is important to explain the wrinkles appearance.

TENSYLINE^® is manufactured using aseptic filling technique under lyophilized presentation in sterile, preservative free and pyrogen free conditions and is intended to be used on several aesthetic techniques, roller, IPL, and other invasive or non-invasive procedures.